Chances are slim.

机会很小。

Are you sure?

你确信吗？

I wonder what happened to him.

我不知道他出什么事了。

The failure drove him hito despair.

这次失败使他绝望。

Don't take any notice of what he says-he's pulling your leg.

别理睬他，他在跟你开玩笑。

He is up to his ears in debt.

他债台高筑。